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The effects of periodontal therapy on gingival crevicular fluid matrix metalloproteinase‐8, interleukin‐6 and prostaglandin E~2~ levels in patients with rheumatoid arthritis by Ş. Kurgan; Ö. Fentoğlu; C. Önder; M. Serdar; F. Eser; D. N. Tatakis; M. Günhan is a Dentistry article available to read on EtoBox.

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## Objective: The aim of this study was to evaluate the effects of non-surgical periodontal therapy on gingival crevicular fluid levels of matrix metalloproteinase-8 (mmp-8), interleukin-6 (il-6) and prostaglandin e2 (pge2 ) in patients with rheumatoid arthritis (ra) with periodontal disease. ## Material and methods: Twenty-seven patients with gingivitis and periodontitis with ra, 26 patients with gingivitis and periodontitis that were systemically healthy and 13 periodontally and systemically healthy volunteers (control group) were included in this study. ra activity was assessed by disease activity score test. the clinical periodontal parameters, fasting venous blood and gingival crevicular fluid samples were obtained and gingival crevicular fluid mmp-8, il-6 and pge2 levels were evaluated at baseline and at 3 mo follow-up after non-surgical periodontal treatment. ## Results: Gingival crevicular fluid mmp-8, pge2 and il-6 levels were higher in all groups than the control group. following periodontal therapy, there were significant decreases in gingival crevicular fluid mmp-8, pge2 and il-6 levels from patients with ra with periodontitis (p < 0.05). plaque index, gingival index an

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Author

Ş. Kurgan; Ö. Fentoğlu; C. Önder; M. Serdar; F. Eser; D. N. Tatakis; M. Günhan

Publisher

Wiley

Published

2015

Language

EN

Field

Dentistry (Health Sciences)