About this Medicine article

Correlation between tumor blood flow assessed by perfusion CT and effect of neoadjuvant therapy in advanced esophageal cancers by Yoichi Makari; Takushi Yasuda; Yuichiro Doki; Hiroshi Miyata; Yoshiyuki Fujiwara; Shuji Takiguchi; Jin Matsuyama; Makoto Yamasaki; Takafumi Hirao; Mitsuhiro Koyama Koyama; Hironobu Nakamuara; Morito Monden is a Medicine article available to read on EtoBox.

## Abstract ## Background Redundant blood supply by angiogenesis is a great advantage for the continuous growth of solid tumors. However, with chemotherapy (ChT), it can be disadvantageous due to increased drug delivery. An objective, reproducible, and non‐invasive method for evaluating tumor blood supply is offered by perfusion CT. ## Methods Fifty‐five advanced esophageal cancers (95% squamous cell carcinomas) were evaluated for hemodynamic parameters, including blood flow (BF), blood volume (BV), and mean transit time (MTT) of primary tumor by perfusion CT scan. Forty‐six underwent neoadjuvant therapy (36 ChT and 10 chemoradiotherapy (CRT)) as primary treatment of the cancer and 36 underwent esophagectomy. ## Results Clinicopathological parameters were not significantly associated with hemodynamic parameters, except for hematogenic metastasis, which was not frequent (seven patients), but significantly associated with high BF (__P__ = 0.0165). High BF and low MTT correlated significantly with a good response by neoadjuvant therapies (__P__ = 0.0004 and __P__ = 0.0124), while BV did not. The patients with high BF more frequently underwent esophagectomy and displayed better prognos

Author

Yoichi Makari; Takushi Yasuda; Yuichiro Doki; Hiroshi Miyata; Yoshiyuki Fujiwara; Shuji Takiguchi; Jin Matsuyama; Makoto Yamasaki; Takafumi Hirao; Mitsuhiro Koyama Koyama; Hironobu Nakamuara; Morito Monden

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0022-4790)

Published

2007

Language

EN

Field

Medicine (Health Sciences)