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Two Genetic Variants in Prostate Stem Cell Antigen and Gastric Cancer Susceptibility in a Chinese Population by Chen Wu; Guanghai Wang; Ming Yang; Liming Huang; Dianke Yu; Wen Tan; Dongxin Lin is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Abstract Genetic factors play important roles in pathogenesis of human cancer. A recent genome‐wide association study (GWAS) linked two single nucleotide polymorphisms (SNPs) in prostate stem cell antigen (__PSCA__), rs2294008C>T and rs2976392G>A, to risk of diffuse‐type of gastric cancer in Japanese and Korean populations. We hypothesized that these two SNPs are also associated with risk of gastric cancer in Chinese population. We examined genotypes and haplotypes of __PSCA__, rs2294008C/T and rs2976392G/A in 716 patients with cardia gastric carcinoma (CGC), 1020 patients with noncardia gastric carcinoma (NCGC), and 1020 controls. We found that individuals with at least one copy of the rs2294008T allele (CT or TT genotype) had an elevated risk for developing NCGC compared with those without this allele (OR = 1.35, 95% CI = 1.13–1.61). Individuals with at least one copy of the rs2976392A allele (GA or AA genotype) had nonsignificantly increased risk for NCGC compared with those without this allele (OR = 1.20, 95% CI = 1.01–1.43). Stratification analysis showed that the increased risk associated with the SNPs was restricted in female subjects. Moreover, the rs2294008T and rs29763

Who reads Two Genetic Variants in Prostate Stem Cell Antigen and Gastric Cancer Susceptibility in a Chinese Population?

Author

Chen Wu; Guanghai Wang; Ming Yang; Liming Huang; Dianke Yu; Wen Tan; Dongxin Lin

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0899-1987)

Published

2009

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)