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Effect of Drying Technique and Disintegrant on Physical Properties and Drug Release Behavior of Microcrystalline Cellulose-based Pellets Prepared by Extrusion/spheronization by Jörg C. Wlosnewski; Mont Kumpugdee-Vollrath; Pornsak Sriamornsak is a Engineering article available to read on EtoBox.

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The aim of this study was to investigate the influence of drying technique and disintegrant on physical properties and drug release behavior of microcrystalline cellulose-based pellets prepared by extrusion/spheronization. Formulations of paracetamol (6.7%, w/w), microcrystalline cellulose (66.7%, w/w) and different disintegrants, alginic acid, calcium carbonate, d-mannitol, croscarmellose sodium, sodium starch glycolate, crospovidone, in concentrations of 10% or 20% (w/w) were made and processed to pellets by extrusion/spheronization. Different drying techniques, i.e. hot-air drying, microwave drying and freeze-drying, were applied to each formulation. Physical properties, such as particle size distribution, moisture content, apparent density, pellet morphology, were evaluated. The mechanical properties and drug release behavior of the pellets were also examined. Only small difference in crushing strength between hot-air dried and microwave-dried pellets were found. Freeze-drying process resulted in pellets with larger diameter, weaker and more porous than pellets dried with the other processes. The porous structure promoted a faster drug release while the drug release from hot-ai

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Author

Jörg C. Wlosnewski; Mont Kumpugdee-Vollrath; Pornsak Sriamornsak

Publisher

Institution of Chemical Engineers; Elsevier ; Institute of Chemical Engineers; Elsevier BV (ISSN 0263-8762)

Published

2010

Language

EN

Field

Engineering (Physical Sciences)