Can I read Influence of Amorphous Content on Compaction Behaviour of Anhydrous α-Lactose on EtoBox?
Influence of Amorphous Content on Compaction Behaviour of Anhydrous α-Lactose by S. Ziffels; H. Steckel is a Pharmacology, Toxicology and Pharmaceutics article available to read on EtoBox.
What is Influence of Amorphous Content on Compaction Behaviour of Anhydrous α-Lactose about?
Modified lactoses are widely used as filler-binders in direct compression of tablets. Until today, little about the compaction behaviour of anhydrous alpha-lactose is known. In this study, a new method to prepare anhydrous alpha-lactose from alpha-lactose monohydrate by desiccation with heated ethanol was evaluated and the influence of amorphous content in the lactose powder prior to modification on powder properties, compaction behaviour and storage stability was determined. The modification process led to anhydrous alpha-lactose with decreased bulk and tapped density, increased flow rate and significantly higher specific surface area. Due to the higher specific surface area, the compaction behaviour of the anhydrous alpha-lactose was found to be significantly better than the compaction behaviour of powder blends consisting of alpha-lactose monohydrate and amorphous lactose. An influence of the amorphous content prior to modification could be observed only at higher compaction forces. In general, tablets of modified powders needed longer time to disintegrate directly after compression. However, the storage stability of modified tablets was found to be better compared to the amorph
Who reads Influence of Amorphous Content on Compaction Behaviour of Anhydrous α-Lactose?
It is typically read by researchers, students, and practitioners in Pharmacology, Toxicology and Pharmaceutics.
- Author
- S. Ziffels; H. Steckel
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0378-5173)
- Published
- 2010
- Language
- EN
- Field
- Pharmacology, Toxicology and Pharmaceutics (Life Sciences)