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Review of L-tyrosine confirming its safe human use as an adjuvant by Paul Baldrick; Derek Richardson; Alan W. Wheeler is a Environmental Science article available to read on EtoBox.

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## Abstract Although there is a long history of exposure to allergy vaccines containing L‐tyrosine, there has been no central publication reviewing its adjuvant properties in animal and human studies together with an assessment of its safe use. This paper summarizes a range of investigational data (unpublished) available to the authors as well as published literature reports. An array of __in vitro__ and __in vivo__ studies showed that L‐tyrosine has ideal adjuvant properties, comprising a high adsorptive power for proteins, enhancement of IgG antibody induction with no stimulatory effect on IgE antibody level and action as a short‐term depot adjuvant, delaying the bioavailability of allergenic materials rather than directly influencing immunocompetent cells. A series of preclinical safety investigations comprised single‐dose parenteral studies in the mouse and rat, repeat‐dose parenteral toxicity studies over 28 days in the rat and dog (up to 25 mg kg^−1^ day^−1^) plus genotoxicity and local tolerance studies. No signs of toxicity or genotoxicity were seen; repeat‐dose toxicity studies showed expected white cell and spleen weight immunostimulatory effects; local‐dose site reaction

Who reads Review of L-tyrosine confirming its safe human use as an adjuvant?

Author

Paul Baldrick; Derek Richardson; Alan W. Wheeler

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 0260-437X)

Published

2002

Language

EN

Field

Environmental Science (Physical Sciences)