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Seasonal Variation in Thyroid Function in Over 7,000 Healthy Subjects in an Iodine-sufficient Area and Literature Review by Sayaka Yamada; Kazuhiko Horiguchi; Masako Akuzawa; Koji Sakamaki; Yohnosuke Shimomura; Isao Kobayashi; Yoshitaka Andou; Masanobu Yamada is a Medicine article available to read on EtoBox.
What is Seasonal Variation in Thyroid Function in Over 7,000 Healthy Subjects in an Iodine-sufficient Area and Literature Review about?
## Abstract ## Context Seasonal variation in thyroid function, especially serum free triiodothyronine (FT3) and free thyroxine (FT4) levels, in healthy subjects remains unclear. ## Methods We examined thyroid function, including serum FT3 and FT4 levels, in healthy Japanese subjects using data of more than 7,000 health check-up participants and applied the analysis of means with transformed ranks (ANOMTR) to compare each month. In addition, we reviewed reports published in the last 2 decades. ## Results The median serum thyrotropin (TSH) level was the highest in January (1.61 mIU/L), and the lowest in May (1.16 mIU/L). ANOMTR revealed that serum TSH levels are high in winter and low in summer. Conversely, the median serum FT3 level was higher in July than in other months, and the ANOMTR plot demonstrated serum FT3 levels to be significantly higher in summer and lower in winter. In contrast, serum FT4 levels were more consistent throughout the year, but statistically, those in February and March, October, and November were higher than those in other months. ANOMTR revealed variations in serum FT4 levels to be small through the year but biphasic. ## Conclusions Taken together with pr
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- Author
- Sayaka Yamada; Kazuhiko Horiguchi; Masako Akuzawa; Koji Sakamaki; Yohnosuke Shimomura; Isao Kobayashi; Yoshitaka Andou; Masanobu Yamada
- Publisher
- Oxford University Press
- Published
- 2022
- Language
- EN
- Field
- Medicine (Health Sciences)