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The effect of radio-adaptive doses on HT29 and GM637 cells by Silke B Schwarz; Pamela M Schaffer; Ulrike Kulka; Birgit Ertl-Wagner; Roswitha Hell; Moshe Schaffer is a Medicine article available to read on EtoBox.

What is The effect of radio-adaptive doses on HT29 and GM637 cells about?

## Background The shape of the dose-response curve at low doses differs from the linear quadratic model. The effect of a radio-adaptive response is the centre of many studies and well known inspite that the clinical applications are still rarely considered. ## Methods We studied the effect of a low-dose pre-irradiation (0.03 Gy – 0.1 Gy) alone or followed by a 2.0 Gy challenging dose 4 h later on the survival of the HT29 cell line (human colorectal cancer cells) and on the GM637 cell line (human fibroblasts). ## Results 0.03 Gy given alone did not have a significant effect on both cell lines, the other low doses alone significantly reduced the cell survival. Applied 4 h before the 2.0 Gy fraction, 0.03 Gy led to a significant induced radioresistance in GM637 cells, but not in HT29 cells, and 0.05 Gy led to a significant hyperradiosensitivity in HT29 cells, but not in GM637 cells. ## Conclusion A pre-irradiation with 0.03 Gy can protect normal fibroblasts, but not colorectal cancer cells, from damage induced by an irradiation of 2.0 Gy and the application of 0.05 Gy prior to the 2.0 Gy fraction can enhance the cell killing of colorectal cancer cells while not additionally damaging n

Who reads The effect of radio-adaptive doses on HT29 and GM637 cells?

Author

Silke B Schwarz; Pamela M Schaffer; Ulrike Kulka; Birgit Ertl-Wagner; Roswitha Hell; Moshe Schaffer

Publisher

BioMed Central; Springer (Biomed Central Ltd.); [London]: BioMed Central, 2006-; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 1748-717X)

Published

2008

Language

EN

Field

Medicine (Health Sciences)