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Efficacy and Indications of Gamma Knife Radiosurgery for Recurrent Low-and High-grade Glioma by Ying Sun; Peiru Liu; Zixi Wang; Haibo Zhang; Ying Xu; Shenghui Hu; Ying Yan is a Medicine article available to read on EtoBox.
What is Efficacy and Indications of Gamma Knife Radiosurgery for Recurrent Low-and High-grade Glioma about?
## Purpose To investigate the indications and efficacy of gamma knife radiosurgery (GKRS) as a salvage treatment for recurrent low-and high-grade glioma. ## Methods This retrospective study of 107 patients with recurrent glioma treated with GKRS between 2009 and 2022, including 68 high-grade glioma (HGG) and 39 low-grade glioma (LGG) cases. The Kaplan-Meier method was used to calculate the overall survival (OS) and progression-free survival (PFS). The log-rank test was used to analyze the multivariate prognosis of the Cox proportional hazards model. Adverse reactions were evaluated according to the __Common Terminology Criteria for Adverse Events version 4.03__. The prognostic value of main clinical features was estimated, including histopathology, Karnofsky performance status (KPS), recurrence time interval, target location, two or more GKRS, surgery for recurrence, site of recurrence, left or right side of the brain and so on. ## Results The median follow-up time was 74.5 months. The median OS and PFS were 17.0 months and 5.5 months for all patients. The median OS and PFS were 11.0 months and 5.0 months for HGG, respectively. The median OS and PFS were 49.0 months and 12.0 months
Who reads Efficacy and Indications of Gamma Knife Radiosurgery for Recurrent Low-and High-grade Glioma?
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- Author
- Ying Sun; Peiru Liu; Zixi Wang; Haibo Zhang; Ying Xu; Shenghui Hu; Ying Yan
- Publisher
- BioMed Central
- Published
- 2024
- Language
- EN
- Field
- Medicine (Health Sciences)