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Morphological, teratogenic and behavioral evaluations of Gelidium spinosum methanol extract on zebrafish embryos by Warsi Warsi; Irwandi Jaswir; Qamar Uddin Ahmed; Nurkhasanah Mahfudh; Mohamed Sufian bin Mohd. Nawi; Abdul Rohman; Alfi Khatib is a Medicine article available to read on EtoBox.

What is Morphological, teratogenic and behavioral evaluations of Gelidium spinosum methanol extract on zebrafish embryos about?

__Gelidium spinosum__ is an edible red seaweed from the family Gelidiaceae with possibility to be developed. The potential medical benefits of __G. spinosum__ have been established, yet adequate empirical research on its toxicity is still lacking. Hence, the present work was aimed to examine the toxicity of __G. spinosum__ methanol extract (GsME) on zebrafish (__Danio rerio__) embryos and to identify the phytoconstituents using gas chromatography-mass spectrometry (GC-MS) analysis. Results of this study showed that GsME induced morphological defects in zebrafish embryos, including reduction in eye size and body length. Moreover, yolk sac size and mortality were increased in zebrafish embryos exposed to GsME in a dose-dependent manner. GsME at high concentrations triggered teratogenic effects in zebrafish embryos such as decrease in heartbeat/minute, lack of pigmentation, lack of somite, structural deformity, pericardial oedema, and yolk oedema. The LC~50~ and EC~50~ of GsME were 1, indicating its teratogenic attribute. Additionally, GsME exerted behavioral effects i.e. significantly lower total distance of movement and slower swimming speed of zebrafish embryos. GC-MS analysis of

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Author

Warsi Warsi; Irwandi Jaswir; Qamar Uddin Ahmed; Nurkhasanah Mahfudh; Mohamed Sufian bin Mohd. Nawi; Abdul Rohman; Alfi Khatib

Publisher

Pensoft Publishers

Published

2024

Language

EN

Field

Medicine (Life Sciences)