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Defective post-transcriptional processing of MUC2 mucin in ulcerative colitis and in Crohn's disease increases detectability of the MUC2 protein core by Hanski, C.; Born, M.; Foss, H. D.; Marowski, B.; Mansmann, U.; Arasth, K.; Bachler, B.; Papenfu, M.; Niedobitek, F. is a Medicine article available to read on EtoBox.
What is Defective post-transcriptional processing of MUC2 mucin in ulcerative colitis and in Crohn's disease increases detectability of the MUC2 protein core about?
Ulcerative colitis (UC) and, to a lesser extent, Crohn's disease (CD) are associated with a reduction of the protective mucus layer in the large intestine; the role of this alteration in the pathogenesis of either disease is, however, not clear. To learn more about the molecular mechanism of the alteration of the mucus layer, the expression of the main intestinal mucin, MUC2, was investigated in relation to inflammation and dysplasia. Formalin-fixed, paraffin-embedded biopsies from 70 patients with UC and 16 patients with CD, and 13 biopsies from normal colonic mucosa, were used for detection of MUC2 mRNA by in situ hybridization with the SMUC41 probe, and MUC2 protein by immunohistochemistry with the antibody CCP58. The steady-state concentration of MUC2 mRNA was not affected by UC or CD. By contrast, the amount of the detectable MUC2 protein, assessed as the immunoreactive score (IRS), was significantly (p<0•0001) increased in UC (IRS=8•0 3•8) and CD (8•0 3•7), compared with the normal colonic mucosa (IRS=2•0 1•5). This alteration occurred in the inactive phase of inflammation and persisted in the active phase of the disease. It was also observed during bacterial or protozoal inf
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- Author
- Hanski, C.; Born, M.; Foss, H. D.; Marowski, B.; Mansmann, U.; Arasth, K.; Bachler, B.; Papenfu, M.; Niedobitek, F.
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0022-3417)
- Published
- 1999
- Language
- EN
- Field
- Medicine (Health Sciences)