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Influence of Glycine on the Damage Induced in Isolated Perfused Rat Liver by Five Hepatotoxic Agents by M Deters; C.-P Siegers; O Strubelt is a Environmental Science article available to read on EtoBox.

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Livers of fasted rats were perfused over 120 min in a recirculating hemoglobin-free system. Hepatotoxic injury induced by the addition of 1-butanol (130.2 mmol/l), CdCl 2 (0.1 mmol/l), CuCl 2 (0.03 mmol/l), Na 3 VO 4 (2 mmol/l) or t-butylhydroperoxide (t-BuOOH, 0.5 mmol/l) to the perfusate was shown by strong increases in lactate dehydrogenase (LDH) and glutamate-pyruvate transaminase (GPT) release, decreased oxygen consumption between 50 and 60%, and a nearly complete suppression of bile flow. Hepatic adenosine triphosphate (ATP) and reduced glutathione (GSH) concentrations were reduced by between 30 and 80%, and 20 and 80%, respectively. Only Na 3 VO 4 and t-BuOOH evoked increased releases of glutamate dehydrogenase (GLDH) in the perfusate. Malondialdehyde (MDA) concentrations were enhanced by all toxicants in the perfusate and by all except 1-butanol in the liver. The MDA increase, however, was much higher after Na 3 VO 4 and t-BuOOH than after the other toxicants. When glycine (12 mmol/l) was added 30 min before the toxicants to the perfusate it prevented the enzyme releases induced by all hepatotoxic agents by about 80%. Furthermore, glycine prevented the Na 3 VO 4 induced inc

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Author

M Deters; C.-P Siegers; O Strubelt

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0300-483X)

Published

1998

Language

EN

Field

Environmental Science (Life Sciences)