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Regioselective anthranoylation of demethylated aconitine: Novel analogues of aconitine inuline and methyllycaconitine by David J. Hardick; Ian S. Blagbrough; Susan Wonnacott; Barry V.L. Potter is a Chemistry article available to read on EtoBox.

What is Regioselective anthranoylation of demethylated aconitine: Novel analogues of aconitine inuline and methyllycaconitine about?

Manyxlmlrauyoccurring '~d~alkaloiidisplayimpartantbiologicalactivitiesdsemisynthesis has been used to prepare several analogues of these basesPS5 There is an urgent requirement to identify selective phazmaml ogicalrespomestosuchalkaloidsinordertodelineatcstructurc-activity relationships (SAR) and to clisseq wherever possible, toxic from bemficial activities. Thus, aconitine (1) is a potent ne tlmoxin6, acting by modulating voltage-sensitive sodium channels, but the related nordi~Oid alkaloid methyllycaumitine (MIA) (2) is the most potent, non-pm&acam, neumnal niminic acetylcholine.

Who reads Regioselective anthranoylation of demethylated aconitine: Novel analogues of aconitine inuline and methyllycaconitine?

Author

David J. Hardick; Ian S. Blagbrough; Susan Wonnacott; Barry V.L. Potter

Publisher

Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0040-4039)

Published

1994

Language

ZU

Field

Chemistry (Physical Sciences)