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MTOR inhibition for cancer therapy : past, present and future by Mita, Monica, editor; Mita, Alain, editor; Rowinsky, Eric K., 1956- editor is a nonfiction available to read on EtoBox.

What is MTOR inhibition for cancer therapy : past, present and future about?

1 online resource (vi, 300 pages) : This book describes the challenges involved in developing mTOR inhibitors for cancer treatment, starting with an in-depth examination of their molecular mechanism of action, with emphasis on the class side-effects, efficacy and mechanisms of resistance, as well as on promising novel directions for their development, including novel compounds and rational combinations with other anti-neoplastic drugs. Over the last 10 years, inhibitors of mTOR have emerged as a major class of anticancer drugs. Two rapamycin analogs are currently approved for the treatment of renal cell carcinoma, and it is estimated that a variety of other tumor types could benefit from mTOR inhibition, with numerous clinical trials (including pivotal registration trials) already underway. Second-generation small-molecule inhibitors of the pathway have also shown promise in terms of their superior tolerability and efficacy and are undergoing extensive clinical evaluation, with an estimated 30+ compounds currently under evaluation Forward -- Past -- mTOR inhibitors: a little bit of history -- Present -- The mTOR pathway -- The evolving role of mTOR inhibitors in renal cell carcinom

Who reads MTOR inhibition for cancer therapy : past, present and future?

Author

Mita, Monica, editor; Mita, Alain, editor; Rowinsky, Eric K., 1956- editor

Publisher

Springer London, Limited

Published

2016

Language

EN

ISBN

9782817805573

Category

nonfiction

Subjects

Medical, Medicine