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An overview of cannabis based treatment in Crohn’s disease by Timna Naftali is a Medicine article available to read on EtoBox.

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: Cannabis use among inflammatory bowel disease (IBD) patients is common. There are many studies of various laboratory models demonstrating the anti-inflammatory effect of cannabis, but their translation to human disease is still lacking.: The cannabis plant contains many cannabinoids, that activate the endocannabinoid system. The two most abundant phytocannabinoids are the psychoactive Tetrahydrocannabinol (THC), and the (mostly) anti-inflammatory cannabidiol (CBD). Approximately 15% of IBD patients use cannabis to ameliorate disease symptoms. Unfortunately, so far there are only three small placebo controlled study regarding the use of cannabis in active Crohns disease, combining altogether 93 subjects. Two of the studies showed significant clinical improvement but no improvement in markers of inflammation.: Cannabis seems to have a therapeutic potential in IBD. This potential must not be neglected; however, cannabis research is still at a very early stage. The complexity of the plant and the diversity of different cannabis chemovars create an inherent difficulty in cannabis research. We need more studies investigating the effect of the various cannabis compounds. These effects c

Who reads An overview of cannabis based treatment in Crohn’s disease?

Author

Timna Naftali

Publisher

Expert Reviews; Informa UK (Taylor & Francis); Taylor & Francis; Informa UK Limited (ISSN 1747-4124)

Published

2020

Language

EN

Field

Medicine (Health Sciences)