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Evidence for Acute Neurotoxicity After Chemotherapy by Axel Petzold; Tjeerd Mondria; Jens Kuhle; Maria A. Rocca; Jan Cornelissen; Peter te Boekhorst; Bob Lowenberg; Gavin Giovannoni; Massimo Filippi; Ludwig Kappos; Rogier Hintzen is a Medicine article available to read on EtoBox.

What is Evidence for Acute Neurotoxicity After Chemotherapy about?

## Abstract ## Objective Chronic neurotoxicity is a recognized long‐term complication following chemotherapy in a range of diseases. Neurotoxicity adversely affects patients' quality of life. The objective of this study is to examine whether there is evidence of acute neurotoxicity. ## Methods This prospective study included patients with secondary progressive multiple sclerosis (SPMS‐BMT, n = 14) and hematological malignancies (HM‐BMT, n = 17) receiving chemotherapy as preconditioning for bone marrow transplant. The control groups included SPMS patients matched for demographic and clinical data (SPMS‐PL, n = 14) and healthy controls (n = 14). Neurodegeneration was assessed at baseline and longitudinally (months 1, 2, 3, 6, 9, 12, 24, and 36), combining a clinical scale for disability (Expanded Disability Status Scale [EDSS]), a serum protein biomarker for neurodegeneration (neurofilaments, NfH‐SMI35), and brain atrophy measures (magnetic resonance imaging). ## Results Disability progression was significantly more acute and severe following chemotherapy compared to placebo. Immediately after starting chemotherapy, serum NfH‐SMI35 levels increased in 79% (__p__ < 0.0001) of SPMS‐BMT

Who reads Evidence for Acute Neurotoxicity After Chemotherapy?

Author

Axel Petzold; Tjeerd Mondria; Jens Kuhle; Maria A. Rocca; Jan Cornelissen; Peter te Boekhorst; Bob Lowenberg; Gavin Giovannoni; Massimo Filippi; Ludwig Kappos; Rogier Hintzen

Publisher

Wiley

Published

2010

Language

EN

Field

Medicine (Health Sciences)