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Arg16 Homozygosity of the β2-Adrenergic Receptor Improves the Outcome After β2-Agonist Tocolysis for Preterm Labor by R LANDAU; M MORALES; S ANTONARAKIS; J BLOUIN; R SMILEY is a Medicine article available to read on EtoBox.

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Arg16 homozygosity of the ␤ 2 -adrenergic receptor improves the outcome after ␤ 2 -agonist tocolysis for preterm labor Background: ␤ 2 -Adrenergic receptor (␤ 2 AR) agonists are not consistently successful when administered as tocolytic therapy. The ␤ 2 AR displays genetic variability; an arginine-to-glycine substitution at codon 16 (Arg16Gly) has been shown to increase receptor desensitization in response to agonist exposure, whereas a substitution of glutamate for glutamine at codon 27 (Gln27Glu) decreases down-regulation. We have demonstrated that homozygosity for Arg16 protects against preterm delivery. Our goal was to determine whether ␤ 2 -agonists are more effective in women with the Arg16 genotype and preterm labor. Methods: Sixty white women with preterm labor between 24 and 34 weeks' gestation were treated for 48 hours with intravenous hexoprenaline. The effect of tocolysis and outcome of pregnancy were recorded. The ␤ 2 AR genotypes at codons 16 and 27 of ADRB2 were determined. A control group of 116 women delivered at term was also genotyped. Results: Preterm labor was not associated with ␤ 2 AR genotype at codon 16 (17% of patients with preterm labor were Arg16 homozyg

Who reads Arg16 Homozygosity of the β2-Adrenergic Receptor Improves the Outcome After β2-Agonist Tocolysis for Preterm Labor?

Author

R LANDAU; M MORALES; S ANTONARAKIS; J BLOUIN; R SMILEY

Publisher

Nature Publishing Group; Wiley (Blackwell Publishing); Wiley-Blackwell; Wiley; Springer Science and Business Media LLC; Research Square (ISSN 0009-9236)

Published

2005

Language

EN

Field

Medicine (Health Sciences)