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Can I read Bioenergetics of Rat Prostate Cancer Cell Migration on EtoBox?
Bioenergetics of Rat Prostate Cancer Cell Migration by Kouvroukoglou, Stylianos; Lakkis, Clair L.; Wallace, John D.; Zygourakis, Kyriacos; Epner, Daniel E. is a Medicine article available to read on EtoBox.
What is Bioenergetics of Rat Prostate Cancer Cell Migration about?
## BACKGROUND. Increased cell motility and increased glycolysis are two well-known hallmarks of cancer. We undertook these studies to determine whether increased glycolysis is required for prostate cancer cell locomotion. METHODS. We studied the highly metastatic MatLu cell line, which is a variant of the Dunning R-3327 rat prostate adenocarcinoma model. Using videomicroscopy and computer image analysis, we compared the speed of migration of cells grown in serum-free medium in either the presence or absence of glucose. RESULTS. We found that cells grown in glucose-free, conditioned medium maintained speeds of migration and intracellular ATP levels for 24 hr which were equivalent to those of cells grown in conditioned medium containing glucose. In contrast, migration was significantly inhibited by growth in glucose-free, unconditioned medium. We also tested the effect of antimycin A and rotenone, two inhibitors of mitochondrial electron transport, on cell migration and ATP levels. Antimycin A had no significant effect on either feature, while rotenone slightly inhibited cell migration without affecting ATP levels. CONCLUSIONS. 1) Glycolysis is not necessary for rat prostate cancer c
Who reads Bioenergetics of Rat Prostate Cancer Cell Migration?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Kouvroukoglou, Stylianos; Lakkis, Clair L.; Wallace, John D.; Zygourakis, Kyriacos; Epner, Daniel E.
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0270-4137)
- Published
- 1998
- Language
- EN
- Field
- Medicine (Health Sciences)