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Can I read Acetylcholine and Glutamate Release During Sleep–wakefulness in the Pedunculopontine Tegmental Nucleus and Norepinephrine Changes Regulated by Nitric Oxide on EtoBox?
Acetylcholine and Glutamate Release During Sleep–wakefulness in the Pedunculopontine Tegmental Nucleus and Norepinephrine Changes Regulated by Nitric Oxide by Tohru Kodama; Yoshiko Honda is a Medicine article available to read on EtoBox.
What is Acetylcholine and Glutamate Release During Sleep–wakefulness in the Pedunculopontine Tegmental Nucleus and Norepinephrine Changes Regulated by Nitric Oxide about?
Cholinergic neurons in the pons appear to play a major role in generating rapid eye movement (REM) sleep. In the present study, acetylcholine and glutamate release in the pedunculopontine tegmental nucleus (PPT) during the sleep–waking cycle were investigated by __in vivo__ microdialysis. Acetylcholine release during slow wave sleep (SWS) was significantly lower (__P__ < 0.05) than during REM sleep and wakefulness. On the other hand, glutamate release during wakefulness was higher (__P__ < 0.05) than during REM sleep and SWS. Furthermore, the application of N‐methyl‐D‐aspartate (1 mM) induced a significant increase of nitric oxides (NOx) for 20 min (__P__ < 0.05) and a decrease of norepinephrine for the first 15 min (__P__ = 0.01), indicating NOx regulation on norepinephrine release in PPT.
Who reads Acetylcholine and Glutamate Release During Sleep–wakefulness in the Pedunculopontine Tegmental Nucleus and Norepinephrine Changes Regulated by Nitric Oxide?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Tohru Kodama; Yoshiko Honda
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 1323-1316)
- Published
- 1999
- Language
- EN
- Field
- Medicine (Health Sciences)