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Helicobacter Pylori , Parietal Cell Antibodies and Autoimmune Gastropathy in Type 1 Diabetes Mellitus by C. E. M. De Block; I. H. De Leeuw; J. J. P. M. Bogers; P. A. Pelckmans; M. M. Ieven; E. A. E. Van Marck; V. Van Hoof; E. Máday; K. L. Van Acker; L. F. Van Gaal is a Medicine article available to read on EtoBox.

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## Background: Fifteen to 20% of type 1 diabetic patients exhibit parietal cell antibodies (PCA), which are associated with autoimmune gastritis, hypochlorhydria, iron deficiency and pernicious anaemia. ## Aim: To examine whether __Helicobacter pylori__ infection could explain the high prevalence of PCA and autoimmune gastropathy in diabetes. If so, __H. pylori__ eradication could prevent autoimmune gastritis. ## Methods: In 229 type 1 diabetics (M/F: 135/94; age: 41 ± 12 years) PCA were measured. __H. pylori__ infection was assessed by serology, urea breath test in all and by histology (updated Sydney system) in 88 subjects. Pentagastrin tests were performed in 42 patients. ## Results: Sixty‐nine patients were PCA‐positive. __H. pylori__ infection was present in 72 patients and was negatively associated with HLA‐DQA1\*0103‐B1\*0603 (OR=0.12, __P__=0.015) and positively with DQA1\*0501‐B1\*0201 (OR=1.9, __P__=0.032). PCA‐positivity was linked to HLA‐DQA1\*0501‐B1\*0301 (OR=3.9, __P__=0.017). A link between __H. pylori__ and PCA was observed when PCA‐positivity was defined as a titre ≥ 1/20 (OR=2.0, __P__=0.03), but not if ≥ 1/40 was the cut‐off point. PCA‐positivity, but not __H. p

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Author

C. E. M. De Block; I. H. De Leeuw; J. J. P. M. Bogers; P. A. Pelckmans; M. M. Ieven; E. A. E. Van Marck; V. Van Hoof; E. Máday; K. L. Van Acker; L. F. Van Gaal

Publisher

John Wiley and Sons; Blackwell Publishing; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley; Research Square (ISSN 0269-2813)

Published

2002

Language

EN

Field

Medicine (Health Sciences)