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What is HPLC Method for Trimebutine in Plasma about?

A highly sensitive HPLC method was developed to simultaneously determine trimebutine (TMB) and its metabolite N-monodesmethyltrimebutine (NDTMB) in rat and human plasma. The method demonstrated good resolution, sensitivity, and linear calibration curves, with detection limits of 1 ng/ml for TMB and 5 ng/ml for NDTMB. This assay was utilized for pharmacokinetic studies of TMB in both rats and humans.

Author

Ana Torres

Language

EN