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Chronic Ethanol Consumption Increases Homocysteine Accumulation in Hepatocytes by Anthony J. Barak; Harriet C. Beckenhauer; Kusum K. Kharbanda; Dean J. Tuma is a Medicine article available to read on EtoBox.

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Results of previous studies have shown that chronic ethanol administration impairs methionine synthetase activity and decreases Sadenosylmethionine levels in the liver, indicating interference with homocysteine remethylation. The purpose of the present study was to investigate the effects of chronic ethanol feeding on the accumulation of homocysteine (Hcy), a potentially toxic agent. The research was divided into two experiments. In Experiment A, hepatocytes were isolated from pair-fed control and ethanol-fed rats after 2 weeks of feeding, and the release of Hcy into the medium was determined. Hepatocytes obtained from ethanol-fed rats released twice as much Hcy into the medium as did those obtained from controls. When hepatocytes were challenged by a methionine load, a marked increase in Hcy generation was observed, and the increase was further enhanced in hepatocytes obtained from ethanol-fed rats. In Experiment B, hepatocytes were isolated from pair-fed control and ethanol-fed rats after 4 weeks of feeding (the feeding time required for significant formation of alcoholic fatty liver in rats). In this experiment, similar results were obtained with Hcy generation as in Experiment

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Author

Anthony J. Barak; Harriet C. Beckenhauer; Kusum K. Kharbanda; Dean J. Tuma

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0741-8329)

Published

2001

Language

EN

Field

Medicine (Health Sciences)