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Tolerability and efficacy of single‐dose diethyl carbamazine (DEC) or ivermectin in the clearance of Wuchereria bancrofti microfilaraemia in Pondicherry, south India by G. Subramanyam Reddy; N. Vengatesvarlou; P. K. Das; P. Vanamail; A. P. Vijayan; Sasi Kala; S. P. Pani is a Medicine article available to read on EtoBox.

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**Summary** In a double blind design the tolerability and efficacy of single‐dose DEC (6 mg/kg/body weight) or ivermectin (400 μg/kg/body weight) was studied in 30 asymptomatic __W. bancrofti__ parasite carriers each. Although both drugs were tolerated well, the adverse reaction score (DEC 0.5; ivermectin 1.5) and overall incidence (DEC 65.0%; ivermectin 93.3%) were significantly higher in the ivermectin group. Major adverse reactions were fever, headache and myalgia, all of which peaked on the second day post‐therapy. Efficacy was measured in terms of proportion of cases clearing parasitaemia and reduction in mean parasite density compared to pre‐therapy levels. Although at the end of one year the ivermectin group showed a significantly higher efficacy (34.8%, 97.0%) compared to DEC (8.3%, 83.8%), at the end of the second year there was no significant difference in efficacy between the drugs (73.7%, 99.5% for ivermectin; 47.8%, 98.9% for DEC). The tolerability and efficacy of the two drugs were not significantly different between gender, age and weight classes of patients.

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Author

G. Subramanyam Reddy; N. Vengatesvarlou; P. K. Das; P. Vanamail; A. P. Vijayan; Sasi Kala; S. P. Pani

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley; ScienceOpen (ISSN 1360-2276)

Published

2000

Language

EN

Field

Medicine (Health Sciences)