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Exercise-induced specialized proresolving mediators stimulate AMPK phosphorylation to promote mitochondrial respiration in macrophages by Ernesto Pena Calderin; Jing-Juan Zheng; Nolan L. Boyd; Lindsey McNally; Timothy N. Audam; Pawel Lorkiewicz; Bradford G. Hill; Jason Hellmann is a Medicine article available to read on EtoBox.

What is Exercise-induced specialized proresolving mediators stimulate AMPK phosphorylation to promote mitochondrial respiration in macrophages about?

## Objective Physical activity has been shown to reduce the risk of CVD mortality in large-cohort longitudinal studies; however, the mechanisms underpinning the beneficial effects of exercise remain incompletely understood. Emerging data suggest that the risk reducing effect of exercise extends beyond changes in traditional CVD risk factors alone and involves alterations in immunity and reductions in inflammatory mediator production. Our study aimed to determine whether exercise-enhanced production of proresolving lipid mediators contribute to alterations in macrophage intermediary metabolism, which may contribute to the anti-inflammatory effects of exercise. ## Methods Changes in lipid mediators and macrophage metabolism were assessed in C57Bl/6 mice following 4 weeks of voluntary exercise training. To investigate whether exercise-stimulated upregulation of specialized proresolving lipid mediators (SPMs) was sufficient to enhance mitochondrial respiration, both macrophages from control mice and human donors were incubated __in vitro__ with SPMs and mitochondrial respiratory parameters were measured using extracellular flux analysis. Compound-C, an ATP-competitive inhibitor of AMPK

Who reads Exercise-induced specialized proresolving mediators stimulate AMPK phosphorylation to promote mitochondrial respiration in macrophages?

Author

Ernesto Pena Calderin; Jing-Juan Zheng; Nolan L. Boyd; Lindsey McNally; Timothy N. Audam; Pawel Lorkiewicz; Bradford G. Hill; Jason Hellmann

Publisher

Elsevier BV

Published

2022

Language

EN

Field

Medicine (Health Sciences)