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Continuum Models of Collective Cell Migration by Banerjee, Shiladitya; Marchetti, M. Cristina is a scholarly article available to read on EtoBox.

What is Continuum Models of Collective Cell Migration about?

Collective cell migration plays a central role in tissue development, morphogenesis, wound repair and cancer progression. With the growing realization that physical forces mediate cell motility in development and physiology, a key biological question is how cells integrate molecular activities for force generation on multicellular scales. In this review we discuss recent advances in modeling collective cell migration using quantitative tools and approaches rooted in soft matter physics. We focus on theoretical models of cell aggregates as continuous active media, where the feedback between mechanical forces and regulatory biochemistry gives rise to rich collective dynamical behavior. This class of models provides a powerful predictive framework for the physiological dynamics that underlies many developmental processes, where cells need to collectively migrate like a viscous fluid to reach a target region, and then stiffen to support mechanical stresses and maintain tissue cohesion.

Author

Banerjee, Shiladitya; Marchetti, M. Cristina

Published

2018

Language

EN