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Condensation Oscillations in the Peptidization of Phenylglycine by Mieczysław Sajewicz; Monika Gontarska; Dorota Kronenbach; Marcin Leda; Teresa Kowalska; Irving R Epstein is a scholarly article available to read on EtoBox.

What is Condensation Oscillations in the Peptidization of Phenylglycine about?

## Abstract In earlier studies, we showed that certain low-molecular-weight carboxylic acids (profens, amino acids, hydroxy acids) can undergo spontaneous __in vitro__ chiral conversion accompanied by condensation to from oligomers, and we proposed two simple models to describe these processes. Here, we present the results of investigations using non-chiral high-performance liquid chromatography with diode array detector (HPLC-DAD) and mass spectrometry (MS) on the dynamics of peptidization of __S__-, __R__-, and __rac__-phenylglycine dissolved in 70% aqueous ethanol and stored for times up to one year. The experimental results demonstrate that peptidization of phenylglycine can occur in an oscillatory fashion. We also describe, and carry out simulations with, three models that capture key aspects of the oscillatory condensation and chiral conversion processes.

Author

Mieczysław Sajewicz; Monika Gontarska; Dorota Kronenbach; Marcin Leda; Teresa Kowalska; Irving R Epstein

Publisher

Chemistry Central; Springer (Biomed Central Ltd.); [London]: Chemistry Central, 2010-2015; [Zurich]: 2019-; Springer Science and Business Media LLC (ISSN 1759-2208)

Published

2010

Language

EN

ISBN

9781759220819