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This study investigates the relationship between codon usage and translational efficiency in eukaryotes, specifically in the budding yeast Saccharomyces cerevisiae. Contrary to the belief that preferred codons are translated faster, the research finds that translational speeds among synonymous codons are similar, suggesting that codon usage is optimized based on cognate tRNA concentrations. The findings highlight a new mechanism for enhancing translational efficiency and indicate natural selection for codon

Author

JianRong Philip Yang

Language

EN