Can I read Sequence Periodicity and Secondary Structure Propensity in Model Proteins on EtoBox?

Sequence Periodicity and Secondary Structure Propensity in Model Proteins by Giovanni Bellesia; Andrew Iain Jewett; Joan-Emma Shea is a scholarly article available to read on EtoBox.

What is Sequence Periodicity and Secondary Structure Propensity in Model Proteins about?

## Abstract We explore the question of whether local effects (originating from the amino acids intrinsic secondary structure propensities) or nonlocal effects (reflecting the sequence of amino acids as a whole) play a larger role in determining the fold of globular proteins. Earlier circular dichroism studies have shown that the pattern of polar, non polar amino acids (nonlocal effect) dominates over the amino acid intrinsic propensity (local effect) in determining the secondary structure of oligomeric peptides. In this article, we present a coarse grained computational model that allows us to quantitatively estimate the role of local and nonlocal factors in determining both the secondary and tertiary structure of small, globular proteins. The amino acid intrinsic secondary structure propensity is modeled by a dihedral potential term. This dihedral potential is parametrized to match with experimental measurements of secondary structure propensity. Similarly, the magnitude of the attraction between hydrophobic residues is parametrized to match the experimental transfer free energies of hydrophobic amino acids. Under these parametrization conditions, we systematically explore the deg

Author

Giovanni Bellesia; Andrew Iain Jewett; Joan-Emma Shea

Publisher

Cold Spring Harbor Laboratory Press; Wiley (John Wiley & Sons); Wiley-Blackwell; Wiley (ISSN 0961-8368)

Published

2010

Language

EN