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Search for Early Pancreatic Cancer Blood Biomarkers in Five European Prospective Population Biobanks Using Metabolomics by Jesse Fest; Lisanne S Vijfhuizen; Jelle J Goeman; Olga Veth; Anni Joensuu; Markus Perola; Satu Männistö; Eivind Ness-Jensen; Kristian Hveem; Toomas Haller; Neeme Tonisson; Kairit Mikkel; Andres Metspalu; Cornelia M van Duijn; Arfan Ikram; Bruno H Stricker; Rikje Ruiter; Casper H J van Eijck; Gert-Jan B van Ommen; Peter A C ʼt Hoen is a Medicine article available to read on EtoBox.
What is Search for Early Pancreatic Cancer Blood Biomarkers in Five European Prospective Population Biobanks Using Metabolomics about?
## Abstract Most patients with pancreatic cancer present with advanced disease and die within the first year after diagnosis. Predictive biomarkers that signal the presence of pancreatic cancer in an early stage are desperately needed. We aimed to identify new and validate previously found plasma metabolomic biomarkers associated with early stages of pancreatic cancer. Prediagnostic blood samples from individuals who were to receive a diagnosis of pancreatic cancer between 1 month and 17 years after sampling (N = 356) and age- and sex-matched controls (N = 887) were collected from five large population cohorts (HUNT2, HUNT3, FINRISK, Estonian Biobank, Rotterdam Study). We applied proton nuclear magnetic resonance–based metabolomics on the Nightingale platform. Logistic regression identified two interesting hits: glutamine (P = 0.011) and histidine (P = 0.012), with Westfall–Young family-wise error rate adjusted P values of 0.43 for both. Stratification in quintiles showed a 1.5-fold elevated risk for the lowest 20% of glutamine and a 2.2-fold increased risk for the lowest 20% of histidine. Stratification by time to diagnosis suggested glutamine to be involved in an earlier process
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- Author
- Jesse Fest; Lisanne S Vijfhuizen; Jelle J Goeman; Olga Veth; Anni Joensuu; Markus Perola; Satu Männistö; Eivind Ness-Jensen; Kristian Hveem; Toomas Haller; Neeme Tonisson; Kairit Mikkel; Andres Metspalu; Cornelia M van Duijn; Arfan Ikram; Bruno H Stricker; Rikje Ruiter; Casper H J van Eijck; Gert-Jan B van Ommen; Peter A C ʼt Hoen
- Publisher
- The Endocrine Society
- Published
- 2019
- Language
- EN
- Field
- Medicine (Health Sciences)