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[1] The document presents research on developing a new formulation of kshar sutra using ingredients from rasashastra (Indian alchemy) for treating fistula-in-ano. [2] The new kshar sutra was prepared using sulphur, borax, alum, beeswax, and cotton thread. Physicochemical analysis and initial clinical studies on 15 patients showed promising results with healing in 4-6 thread changes. [3] The conclusion is that the new rasashastra-based kshar sutra formulation shows potential for treating fistula-in-ano a

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