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Citric acid cross-linking of a hydrogel from Aloe vera (Aloe barbadensis M.) engenders a pH-responsive, superporous, and smart material for drug delivery by Irfan, Jaffar (author);Ali, Arshad (author);Hussain, Muhammad Ajaz (author);Haseeb, Muhammad Tahir (author);Naeem-ul-Hassan, Muhammad (author);Hussain, Syed Zajif (author) is a Materials Science article available to read on EtoBox.

What is Citric acid cross-linking of a hydrogel from Aloe vera (Aloe barbadensis M.) engenders a pH-responsive, superporous, and smart material for drug delivery about?

The current research work is based on the evaluation of a citric acid (CA) cross-linked __Aloe vera__ (__Aloe barbadensis__ M.) leaf hydrogel (CL-ALH) for pH-dependent and sustained drug release application. The CA was used in different concentrations (1.25, 2.5, 5.0, and 10.0%) to cross-link the ALH using homogenous reaction conditions. The synthesis of CL-ALH was confirmed through Fourier transform and nuclear magnetic resonance spectroscopic studies. The thermal analysis indicated that the ALH and CL-ALH were stable and decomposed in two steps. The scanning electron microscopic images of CL-ALH confirmed its porous nature due to the presence of interconnected channeling. The swelling of CL-ALH was evaluated at pH 1.2, 6.8, and 7.4 as well as in deionized water (DW). High swelling of CL-ALH was observed in DW, and at pH 7.4 and 6.8 whereas, less swelling of CL-ALH was witnessed at pH 1.2. CL-ALH also exhibited swelling/deswelling behavior in DW and ethanol, DW and normal saline, and at pH 7.4 and 1.2. Tablets were prepared from CL-ALH as a release retarding agent demonstrating the sustained release of venlafaxine hydrochloride (VFX) for 8 h. Whereas, VFX was released within 4 h f

Who reads Citric acid cross-linking of a hydrogel from Aloe vera (Aloe barbadensis M.) engenders a pH-responsive, superporous, and smart material for drug delivery?

It is typically read by researchers, students, and practitioners in Materials Science.

Author
Irfan, Jaffar (author);Ali, Arshad (author);Hussain, Muhammad Ajaz (author);Haseeb, Muhammad Tahir (author);Naeem-ul-Hassan, Muhammad (author);Hussain, Syed Zajif (author)
Publisher
Royal Society of Chemistry (RSC)
Published
2024
Language
EN
Field
Materials Science (Physical Sciences)

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