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Initial validation for the estimation of resting-state fMRI effective connectivity by a generalization of the correlation approach by Xu, Nan; Spreng, R. Nathan; Doerschuk, Peter C. is a scholarly article available to read on EtoBox.

What is Initial validation for the estimation of resting-state fMRI effective connectivity by a generalization of the correlation approach about?

Resting-state functional MRI (rs-fMRI) is widely used to noninvasively study human brain networks. Network functional connectivity is often estimated by calculating the timeseries correlation between blood-oxygen-level dependent (BOLD) signal from different regions of interest. However, standard correlation cannot characterize the direction of information flow between regions. In this paper, we introduce and test a new concept, prediction correlation, to estimate effective connectivity in functional brain networks from rs-fMRI. In this approach, the correlation between two BOLD signals is replaced by a correlation between one BOLD signal and a prediction of this signal via a causal system driven by another BOLD signal. Three validations are described: (1) Prediction correlation performed well on simulated data where the ground truth was known, and outperformed four other methods. (2) On simulated data designed to display the "common driver" problem, prediction correlation did not introduce false connections between non-interacting driven ROIs. (3) On experimental data, prediction correlation recovered the previously identified network organization of human brain. Prediction correla

Author

Xu, Nan; Spreng, R. Nathan; Doerschuk, Peter C.

Published

2016

Language

EN