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Patterns of serial CEA assays and their clinical use in management of colorectal cancer by Paul H. Sugarbaker; Arthur T. Skarin; Norman Zamcheck is a Medicine article available to read on EtoBox.

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## Abstract Through persistent clinical research efforts, the CEA test has developed into a useful although complex disease monitor for colorectal cancer. Although improved or prolonged survival from its use has not been demonstrated, CEA monitoring may allow more knowledgeable patient management. Several reports indicate that postoperative serial CEA assays may identify patients with early recurrence, especially when assays are done frequently. Patients with elevated pretreatment CEA levels usually showed progressively rising titers before other objective evidence of recurrence was apparent. A progressively rising CEA titer correlated well with recurrent cancer, but a normal CEA could not be used as proof of its absence. Persistently elevated CEA titers post‐treatment were caused either by persistent disease or by nontumor‐related factors. The CEA assay was not a substitute for clinical follow‐up but was an adjunct in the diagnosis of early recurrence. Patients with elevated CEA levels caused by localized disease treated by radiation therapy demonstrated a marked fall in serial CEA levels if all CEA‐producing tumor was localized within the radiation portal. The use of pretreatment

Who reads Patterns of serial CEA assays and their clinical use in management of colorectal cancer?

Author

Paul H. Sugarbaker; Arthur T. Skarin; Norman Zamcheck

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0022-4790)

Published

1976

Language

EN

ISBN

9782930080611

Field

Medicine (Health Sciences)