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Antecedent use of fluoroquinolones is associated with resistance to moxifloxacin in Clostridium difficile by G. Ackermann; Y. J. Tang-Feldman; R. Schaumann; J. P. Henderson; A. C. Rodloff; J. Silva Jr; S. H. Cohen is a Medicine article available to read on EtoBox.

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## Objective: Moxifloxacin is characterized by high activity against gram-positive cocci and some gram-positive and -negative anaerobes, including clostridium difficile. this study investigates the role of prior quinolone use in relation to patterns of susceptibility of c. difficile to moxifloxacin. ## Methods: Sixty-three clinical isolates of c. difficile were investigated for toxigenicity, susceptibility to moxifloxacin, and mutations in the dna gyrase gene. the medical histories for 50 of these patients were available and used to identify previous fluoroquinolone use. ## Results: Thirty-three (52.4%) strains showed resistance to moxifloxacin (mics > or = 16 mg/l). all moxifloxacin-resistant strains harbored a mutation at amino acid codon ser-83 of gyra. forty-five isolates (71.4%) were toxigenic; all moxifloxacin-resistant strains were in this group. resistance to moxifloxacin was associated with prior use of fluoroquinolones (p-value 0.009, chi-square). ## Conclusions: Although the use of moxifloxacin to treat c. difficile-associated diarrhea is not likely to be common, these data show a relationship between antecedent fluoroquinolone use and resistance to moxifloxacin in c. di

Who reads Antecedent use of fluoroquinolones is associated with resistance to moxifloxacin in Clostridium difficile?

Author

G. Ackermann; Y. J. Tang-Feldman; R. Schaumann; J. P. Henderson; A. C. Rodloff; J. Silva Jr; S. H. Cohen

Publisher

John Wiley and Sons; Elsevier ; Elsevier Limited; Elsevier BV; Test accounts (ISSN 1198-743X)

Published

2003

Language

EN

Field

Medicine (Health Sciences)