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Radiation and chemotherapy combination for nasopharyngeal carcinoma in children: Radiotherapy dose adaptation after chemotherapy response to minimize late effects by Daniel Orbach; Hervé Brisse; Sylvie Helfre; Jerzy Klijanienko; Danielle Bours; Véronique Mosseri; José Rodriguez is a Medicine article available to read on EtoBox.

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## Abstract ## Objectives To retrospectively report the clinical and therapeutic features of children with nasopharyngeal carcinoma (NPC) treated by chemotherapy and doses adapted of radiotherapy. ## Patients and Methods From 1978 to 2005, 34 children were treated for NPC. All histologic and/or cytologic samples and CT scans were reviewed. Cervical nodal irradiation was reduced (<50 Gy) in the case of a good response to chemotherapy (≥90% of initial tumor volume). ## Results Thirty‐two children had metastatic cervical nodes and one child had systemic metastases at diagnosis. All children had AJJC‐TNM Stage IV. Thirty‐one children received neoadjuvant chemotherapy with various regimens. The overall chemotherapy response rate was 78%. Fifteen patients had cervical nodal irradiation dose reduced: Median 47 Gy (range: 45–50). Nasopharyngeal radiotherapy was delivered at a dose of 59.4 Gy (range: 45–66). Local and distant failure rates were 10% and 18%, respectively. The 5‐year overall survival was 73 ± 8% and the event‐free survival (EFS) was 75 ± 8%. ## Conclusions The overall prognosis was not influenced by TNM status, dose of local radiotherapy delivered or response to initial chemo

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Author

Daniel Orbach; Hervé Brisse; Sylvie Helfre; Jerzy Klijanienko; Danielle Bours; Véronique Mosseri; José Rodriguez

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1545-5009)

Published

2007

Language

EN

Field

Medicine (Health Sciences)