Can I read Benign Versus Destructive Insulitis on EtoBox?

Benign Versus Destructive Insulitis by Hubert Kolb is a Medicine article available to read on EtoBox.

What is Benign Versus Destructive Insulitis about?

## Introduction (IDDM) can be expected. [2][3][4] Islet autoimmunity is even being regarded as "protective" when occurring in the presence of HLA DQB1\*0602. 5 The concept of benign versus destructive In the two spontaneous animal models autoimmunity has a new era of diabetes of type 1 diabetes-the BB rat and the NOD research. Islet autoimmunity is no longer mouse-it has been noticed from early on that regarded as dangerous per se. Under certain insulitis develops in close to 100% of animals circumstances islet autoimmunity can even be while overt diabetes is seen in as few as 20% of therapeutic use in that "benign" autoreactive of the animals. [6][7][8] Mononuclear infiltration of T cells can compete with highly aggressive islets without diabetes has also been noticed in autoimmune T cells. Therefore, a large number other animal models, such as the NZB mouse, 9 of therapeutic approaches are in development in graft-versus-host disease, 10 after subtotal which do not aim at the suppression of islet pancreatectomy, 11 insulin antibody injections 12 autoimmunity but attempt to reinforce benign or immunization with insulin or islet constituover destructive autoimmune responses. This en

Who reads Benign Versus Destructive Insulitis?

Author

Hubert Kolb

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0742-4221)

Published

1997

Language

EN

Field

Medicine (Health Sciences)