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Can I read Aspirin Inhibits Inducible Nitric Oxide Synthase Expression and Tumour Necrosis Factor-alpha Release by Cultured Smooth Muscle Cells on EtoBox?
Aspirin Inhibits Inducible Nitric Oxide Synthase Expression and Tumour Necrosis Factor-alpha Release by Cultured Smooth Muscle Cells by L. Sánchez de Miguel; T. De Frutos; F. González-Fernández; V. Del Pozo; C. Lahoz; A. Jiménez; L. Rico; R. García; E. Aceituno; I. Millás; J. Gómez; J. Farré; S. Casado; A. López-Farré is a Medicine article available to read on EtoBox.
What is Aspirin Inhibits Inducible Nitric Oxide Synthase Expression and Tumour Necrosis Factor-alpha Release by Cultured Smooth Muscle Cells about?
## Background: Inflammatory related cardiovascular disease, i.e. cardiac allograft rejection, myocarditis, septic shock, are accompanied by cytokine production, which stimulates the expression of inducible nitric oxide (inos). ## Materials and methods: The aim of the present study was to examine whether anti-inflammatory doses of acetylsalicylic acid (aspirin) could regulate inos protein expression in bovine vascular smooth muscle cells (bvsmcs) in culture. ## Results: Interleukin 1 beta (il-1 beta, 0.03 u ml-1) induced nitric oxide release by bvsmcs. aspirin inhibited nitric oxide release from il-1 beta-stimulated bvsmcs in a dose-dependent manner. in addition, aspirin significantly inhibited inos protein expression in bvsmcs and reduced the translocation of the nuclear factor-kappa b (nf-kappa b). furthermore, aspirin and the blockade of no generation by bvsmcs reduced the production of tumour necrosis factor alpha (tnf-alpha) by these cells. ## Conclusion: High doses of aspirin inhibited inos protein expression in bvsmcs and decreased nf-kappa b mobilization. the inhibition of inos expression by aspirin was further associated with a reduced ability of bvsmcs to produce tnf-alpha
Who reads Aspirin Inhibits Inducible Nitric Oxide Synthase Expression and Tumour Necrosis Factor-alpha Release by Cultured Smooth Muscle Cells?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- L. Sánchez de Miguel; T. De Frutos; F. González-Fernández; V. Del Pozo; C. Lahoz; A. Jiménez; L. Rico; R. García; E. Aceituno; I. Millás; J. Gómez; J. Farré; S. Casado; A. López-Farré
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0014-2972)
- Published
- 1999
- Language
- EN
- Field
- Medicine (Health Sciences)