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Can I read The Neuroepithelial Basement Membrane Serves as a Boundary and a Substrate for Neuron Migration in the Zebrafish Hindbrain on EtoBox?
The Neuroepithelial Basement Membrane Serves as a Boundary and a Substrate for Neuron Migration in the Zebrafish Hindbrain by Paul K Grant; Cecilia B Moens is a Neuroscience article available to read on EtoBox.
What is The Neuroepithelial Basement Membrane Serves as a Boundary and a Substrate for Neuron Migration in the Zebrafish Hindbrain about?
## Background: The facial branchiomotor neurons of cranial nerve vii undergo a stereotyped tangential migration in the zebrafish hindbrain that provides an ideal system for examining the complex interactions between neurons and their environment that result in directed migration. several studies have shown the importance of the planar cell polarity pathway in facial branchiomotor neuron migration but the role of apical-basal polarity has not been determined. here we examine the role of the par-apkc complex in forming the basal structures that guide facial branchiomotor neurons on an appropriate migratory path. ## Results: High resolution timelapse imaging reveals that facial branchiomotor neurons begin their migration by moving slowly ventrally and posteriorly with their centrosomes oriented medially and then, upon contact with the laminin-containing basement membrane at the rhombomere 4-rhombomere 5 boundary, speed up and reorient their centrosomes on the anterior-posterior axis. disruption of the par-apkc complex members apkclambda, apkczeta, and pard6gb results in an ectopic ventral migration in which facial branchiomotor neurons escape from the hindbrain through holes in the la
Who reads The Neuroepithelial Basement Membrane Serves as a Boundary and a Substrate for Neuron Migration in the Zebrafish Hindbrain?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Paul K Grant; Cecilia B Moens
- Publisher
- BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, 2006-; Springer Science and Business Media LLC (ISSN 1749-8104)
- Published
- 2010
- Language
- EN
- Field
- Neuroscience (Life Sciences)