About this Medicine article
Long‐term Follow‐up of Fixed Low‐dose Oral Immunotherapy for Children with Severe Cow’s Milk Allergy by Yoko Miura; Ken‐ichi Nagakura; Makoto Nishino; Mari Takei; Kyohei Takahashi; Tomoyuki Asaumi; Kiyotake Ogura; Sakura Sato; Motohiro Ebisawa; Noriyuki Yanagida is a Medicine article available to read on EtoBox.
## Background: The efficacy and safety of cow's milk (cm) low-dose oral immunotherapy (loit) at one-year follow-up have been previously reported. we investigated the outcome of fixed long-term loit in children with severe cm allergy. ## Methods: Children with positive reactions to oral food challenge (ofc) with 3 ml cm were included. the loit group (n = 33) ingested up to 3 ml cm for 1 year. after a two-week cm avoidance, 3 and 25 ml ofcs were performed. children with positive reactions continued with 3 ml ingestion, with ofcs repeated yearly. regular home consumption of 25 ml cm after passing the ofcs was defined as 25 ml short-term unresponsiveness (25 ml stu). the historical control group (n = 16) with reactions to 3 ml ofc eliminated daily cm ingestion. ## Results: The proportion of 25 ml stu in the loit group was 27%, 52%, and 61% after 1, 2, and 3 years, respectively, and the 3-year percentage was significantly higher than that in the historical control group (13%, p = .002). in the loit group, only one child developed severe symptoms. furthermore, in this group, cm- and casein-specific immunoglobulin e (sige) levels decreased significantly and casein-specific igg and igg lev
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- Author
- Yoko Miura; Ken‐ichi Nagakura; Makoto Nishino; Mari Takei; Kyohei Takahashi; Tomoyuki Asaumi; Kiyotake Ogura; Sakura Sato; Motohiro Ebisawa; Noriyuki Yanagida
- Publisher
- Wiley
- Published
- 2021
- Language
- EN
- Field
- Medicine (Health Sciences)