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Mitochondrial constituents of corpora amylacea and autofluorescent astrocytic inclusions in senescent human brain: CORPORA AMYLACEA CONSTITUENTS by Dr. Hyman M. Schipper; Soriba Cissé is a Neuroscience article available to read on EtoBox.
What is Mitochondrial constituents of corpora amylacea and autofluorescent astrocytic inclusions in senescent human brain: CORPORA AMYLACEA CONSTITUENTS about?
Corpora amylacea (CA) are cytoplasmic inclusions that accumulate in human brain in the course of normal aging, and to an even greater extent, in Alzheimer's disease and other neurodegenerative conditions. In senescent and Alzheimer-diseased human brains, astrocytes in limbic and periventricular regions exhibit red autofluorescent inclusions, homologous to Gomori-positive astrocyte granules previously described in the brains of aging rodents and other vertebrates. We have shown that Gomori inclusions in situ and in culture are derived from autophagocytosed mitochondria exhibiting iron-mediated peroxidase activity. In the human brain, the autofluorescent inclusions share many properties with CA. Both types of inclusion progressively accumulate in periventricular regions with advancing age, are largely astrocytic in origin, and contain various heat shock proteins and ubiquitin. Using histochemistry in conjunction with confocal microscopy, we demonstrated that both CA and the red autofluorescent granules exhibit non-enzymatic peroxidase activity and an affinity for CAH and PAS. The only major divergent histochemical feature between the Gomori-positive astrocyte granules and CA is the p
Who reads Mitochondrial constituents of corpora amylacea and autofluorescent astrocytic inclusions in senescent human brain: CORPORA AMYLACEA CONSTITUENTS?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Dr. Hyman M. Schipper; Soriba Cissé
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 0894-1491)
- Published
- 1995
- Language
- EN
- Field
- Neuroscience (Life Sciences)