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Clinical phenotyping of newly diagnosed type 2 diabetes in Yemen by Abdallah Ahmed Gunaid; Mohammed Mohammed Al-Kebsi; Mahfouth Abdalla Bamashmus; Saleh Ahmed Al-Akily; Ahmed Nasser Al-Radaei is a Medicine article available to read on EtoBox.
What is Clinical phenotyping of newly diagnosed type 2 diabetes in Yemen about?
## Objective To identify clinical phenotypes of type 2 diabetes (T2D) among adults presenting with a first diagnosis of diabetes. ## Research design and methods A total of 500 consecutive patients were subject to clinical assessment and laboratory investigations. We used data-driven cluster analysis to identify phenotypes of T2D based on clinical variables and Homeostasis Model Assessment (HOMA2) of insulin sensitivity and beta-cell function estimated from paired fasting blood glucose and specific insulin levels. ## Results The cluster analysis identified three statistically different clusters: cluster 1 (high insulin resistance and high beta-cell function group), which included patients with low insulin sensitivity and high beta-cell function; cluster 2 (low insulin resistance and low beta-cell function group), which included patients with high insulin sensitivity but very low beta-cell function; and cluster 3 (high insulin resistance and low beta-cell function group), which included patients with low insulin sensitivity and low beta-cell function. Insulin sensitivity, defined as median HOMA2-S, was progressively increasing from cluster 1 (35.4) to cluster 3 (40.9), to cluster 2 (
Who reads Clinical phenotyping of newly diagnosed type 2 diabetes in Yemen?
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- Author
- Abdallah Ahmed Gunaid; Mohammed Mohammed Al-Kebsi; Mahfouth Abdalla Bamashmus; Saleh Ahmed Al-Akily; Ahmed Nasser Al-Radaei
- Publisher
- BMJ
- Published
- 2018
- Language
- EN
- Field
- Medicine (Health Sciences)