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Eugenol isolated from supercritical fluid extract of Ocimum sanctum : a potent inhibitor of DENV-2 by Sulochana Kaushik; Samander Kaushik; Lalit Dar; Jaya Parkash Yadav is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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Dengue is one of the fairly prevalent viral infections at the world level transmitted through mosquitoes (__Aedes aegypti__ and __Aedes albopictus__). Due to various environmental factors, dengue cases surged rapidly at the global level in recent decades, with 193245 cases in 2021 and an increment of 110473 cases in 2022. There is no antidote available against dengue and other __flaviviruses__. In the absence of a dengue vaccine or specific antiviral, medicinal plants or their products can be the only choice for its effective management. __Ocimum sanctum__ is known as ‘‘The Incomparable One,’’ ‘‘Mother Medicine of Nature’’ and ‘‘Queen of Herbs’’ in Ayurveda, and is considered an "elixir of life" supreme in both healthcare and spiritual terms. In present study eugenol was isolated in __O.sanctum.__ Eugenol (1-hydroxy-2-methoxy-4-allylbenzene) has been substantially responsible for its therapeutic potential. High-performance thin-layer chromatography, Fourier transform infrared spectroscopy and ultraviolet–visible spectroscopy were applied to identify the compound. The Rf value of isolated compound was same in the chromatogram (0.69 + 0.05) with compare to standard. The safe dose of

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Author

Sulochana Kaushik; Samander Kaushik; Lalit Dar; Jaya Parkash Yadav

Publisher

Springer Science and Business Media LLC

Published

2023

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)