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Human neural stem cell-derived extracellular vesicles mitigate hallmarks of Alzheimer’s disease by Apodaca, Lauren A. (author);Baddour, Al Anoud D. (author);Garcia, Camilo (author);Alikhani, Leila (author);Giedzinski, Erich (author);Ru, Ning (author);Agrawal, Anshu (author);Acharya, Munjal M. (author);Baulch, Janet E. (author) is a Medicine article available to read on EtoBox.

What is Human neural stem cell-derived extracellular vesicles mitigate hallmarks of Alzheimer’s disease about?

## Abstract ## Background Regenerative therapies to mitigate Alzheimer’s disease (AD) neuropathology have shown very limited success. In the recent era, extracellular vesicles (EVs) derived from multipotent and pluripotent stem cells have shown considerable promise for the treatment of dementia and many neurodegenerative conditions. ## Methods Using the 5xFAD accelerated transgenic mouse model of AD, we now show the regenerative potential of human neural stem cell (hNSC)-derived EVs on the neurocognitive and neuropathologic hallmarks in the AD brain. Two- or 6-month-old 5xFAD mice received single or two intra-venous (retro-orbital vein, RO) injections of hNSC-derived EVs, respectively. ## Results RO treatment using hNSC-derived EVs restored fear extinction memory consolidation and reduced anxiety-related behaviors 4–6 weeks post-injection. EV treatment also significantly reduced dense core amyloid-beta plaque accumulation and microglial activation in both age groups. These results correlated with partial restoration of homeostatic levels of circulating pro-inflammatory cytokines in the AD mice. Importantly, EV treatment protected against synaptic loss in the AD brain that parallele

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Author
Apodaca, Lauren A. (author);Baddour, Al Anoud D. (author);Garcia, Camilo (author);Alikhani, Leila (author);Giedzinski, Erich (author);Ru, Ning (author);Agrawal, Anshu (author);Acharya, Munjal M. (author);Baulch, Janet E. (author)
Publisher
Springer Science and Business Media LLC
Published
2021
Language
EN
Field
Medicine (Health Sciences)

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