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High-resolution Lipidomics Reveals Dysregulation of Lipid Metabolism in Respiratory Syncytial Virus Pneumonia Mice† by Jinjun Shan; Wenjuan Qian; Cunsi Shen; Lili Lin; Tong Xie; Linxiu Peng; Jia Xu; Rui Yang; Jianjian Ji; Xia Zhao is a Materials Science article available to read on EtoBox.
What is High-resolution Lipidomics Reveals Dysregulation of Lipid Metabolism in Respiratory Syncytial Virus Pneumonia Mice† about?
Respiratory syncytial virus (RSV) is a leading viral pathogen responsible for lower respiratory tract infections, particularly in children under five years worldwide, often resulting in hospitalization. At present, the molecular-level interactions between RSV and its host and the underlying mechanisms of RSV-induced inflammation are poorly understood. Herein, we describe an untargeted high-resolution lipidomics platform based on UHPLC-Q-Exactive-MS to assess the lipid alterations of lung tissues and plasma from a mouse model of RSV pneumonia. Untargeted lipidomics using LC-MS with multivariate analysis was applied to describe the lipidomic profiling of the lung tissues and plasma in RSV pneumonia mice. Lipid identification was conducted __via__ an __in silico__ MS/MS LipidBlast library using the MS-DIAL software. We observed distinct compartmental lipid signatures in the mice lung tissues and plasma and significant lipid profile changes between the systematic and localized host responses to RSV. A total of 87 and 68 differential lipids were captured in the mice lung tissue and plasma, respectively, including phospholipids, sphingolipids, acylcarnitine, and fatty acids. Some of thes
Who reads High-resolution Lipidomics Reveals Dysregulation of Lipid Metabolism in Respiratory Syncytial Virus Pneumonia Mice†?
It is typically read by researchers, students, and practitioners in Materials Science.
- Author
- Jinjun Shan; Wenjuan Qian; Cunsi Shen; Lili Lin; Tong Xie; Linxiu Peng; Jia Xu; Rui Yang; Jianjian Ji; Xia Zhao
- Publisher
- The Royal Society of Chemistry
- Published
- 2018
- Language
- EN
- Field
- Materials Science (Physical Sciences)