About this Chemistry article
Synthesis of a novel ester of hydroxytyrosol and α-lipoic acid exhibiting an antiproliferative effect on human colon cancer HT-29 cells by Roberta Bernini; Fernanda Crisante; Nicolò Merendino; Romina Molinari; Maria Chiara Soldatelli; Francesca Velotti is a Chemistry article available to read on EtoBox.
A novel ester of hydroxytyrosol and α-lipoic acid was synthesized in satisfactory yield by original and simple procedures and evaluated about its antiproliferative activity on the human colorectal adenocarcinoma HT-29 cell line. The compound exhibited a cell growth inhibitory activity significantly more potent than the corresponding parent natural compounds, very likely due to the induction of cell cycle arrest in the G2/M phase. These data suggest that the novel ester might exert a more effective antitumour activity than hydroxytyrosol and α-lipoic acid.
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- Author
- Roberta Bernini; Fernanda Crisante; Nicolò Merendino; Romina Molinari; Maria Chiara Soldatelli; Francesca Velotti
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0223-5234)
- Published
- 2011
- Language
- EN
- Field
- Chemistry (Physical Sciences)