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TRPV4 inhibition prevents increased water diffusion and blood-retina barrier breakdown in the retina of streptozotocin-induced diabetic mice by Orduña Ríos, Maricruz; Noguez Imm, Ramsés; Hernández Godínez, Nicole Marilú; Bautista Cortes, Ana María; López Escalante, Dayana Deyanira; Liedtke, Wolfgang; Martínez Torres, Atáulfo; Concha, Luis; Thébault, Stéphanie; Chen, Jing is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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A better understanding of the molecular and cellular mechanisms involved in retinal hydro-mineral homeostasis imbalance during diabetic macular edema (DME) is needed to gain insights into retinal (patho-)physiology that will help elaborate innovative therapies with lower health care costs. Transient receptor potential cation channel subfamily vanilloid member 4 (TRPV4) plays an intricate role in homeostatic processes that needs to be deciphered in normal and diabetic retina. Based on previous findings showing that TRPV4 antagonists resolve blood-retina barrier (BRB) breakdown in diabetic rats, we evaluated whether TRPV4 channel inhibition prevents and reverts retinal edema in streptozotocin(STZ)-induced diabetic mice. We assessed retinal edema using common metrics, including retinal morphology/thickness (histology) and BRB integrity (albumin-associated tracer), and also by quantifying water mobility through apparent diffusion coefficient (ADC) measures. ADC was measured by diffusion-weighted magnetic resonance imaging (DW-MRI), acquired ex vivo at 4 weeks after STZ injection in diabetes and control groups. DWI images were also used to assess retinal thickness. TRPV4 was genetically

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Author

Orduña Ríos, Maricruz; Noguez Imm, Ramsés; Hernández Godínez, Nicole Marilú; Bautista Cortes, Ana María; López Escalante, Dayana Deyanira; Liedtke, Wolfgang; Martínez Torres, Atáulfo; Concha, Luis; Thébault, Stéphanie; Chen, Jing

Publisher

Public Library of Science; San Francisco CA: Public Library of Science; Publons; ScienceOpen; Public Library of Science (PLoS) (ISSN 1932-6203)

Published

2019

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)