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Can I read Increased CCR4 Expression in Cutaneous T Cell Lymphoma on EtoBox?
Increased CCR4 Expression in Cutaneous T Cell Lymphoma by Ferenczi, Katalin; Fuhlbrigge, Robert C; Pinkus, Jack L; Pinkus, Geraldine S; Kupper, Thomas S is a Medicine article available to read on EtoBox.
What is Increased CCR4 Expression in Cutaneous T Cell Lymphoma about?
Chemokines are critical molecules in leukocyte trafficking, promoting site-specific migration to various tissues. The chemokine receptor CCR4 has recently been associated with skin-homing T cells. In view of the potential importance of CCR4 in skin homing of T cells, we investigated the expression pattern of CCR4 and its ligands TARC/CCL17 and MDC/CCL22 in the peripheral blood and skin of patients with cutaneous T cell lymphoma, a putative malignancy of the skin-homing T cells. In this study we analyzed the pattern of coexpression of the skin-homing molecules cutaneous lymphocyte antigen (CLA) and CCR4 in the blood and skin of patients with cutaneous T cell lymphoma. In the blood of cutaneous T cell lymphoma patients with peripheral blood involvement we found significantly increased percentages of T cells displaying the skin-homing phenotype (CLA+CCR4+) compared with healthy individuals. T cells expressing CLA and CCR4 were also found at high levels in cutaneous T cell lymphoma lesions along with abundant expression of the two CCR4 ligands TARC/CCL17 and MDC/CCL22. These data may explain, in part, why these T cells accumulate in the skin, a diagnostic feature of cutaneous T cell ly
Who reads Increased CCR4 Expression in Cutaneous T Cell Lymphoma?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Ferenczi, Katalin; Fuhlbrigge, Robert C; Pinkus, Jack L; Pinkus, Geraldine S; Kupper, Thomas S
- Publisher
- Nature Publishing Group; Elsevier ; Elsevier Inc.; Elsevier BV; Springer Science and Business Media LLC; Wiley (ISSN 0022-202X)
- Published
- 2002
- Language
- EN
- Field
- Medicine (Health Sciences)