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Can I read Parent-of-origin specific effects on the methylation of a transgene in the zebrafish, Danio rerio on EtoBox?
Parent-of-origin specific effects on the methylation of a transgene in the zebrafish, Danio rerio by C. Cristofre Martin; Ross McGowan is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Parent-of-origin specific effects on the methylation of a transgene in the zebrafish, Danio rerio about?
We have examined the inheritance of a transgene locus in the zebrafish, Danio rerio and demonstrated that its methylation is affected by the sex of the parent contributing the allele. This parent-of-origin effect on the zebrafish transgene appears to be identical to imprinting as seen in mammals except that in zebrafish, passage of the locus through a female tended to decreased its methylation, whereas passage through a male increased it. Methylation of the transgene in gametic tissues differed from somatic tissue with the locus being hypomethylated in sperm and hypermethylated in the unfertilized egg. The potential identification of imprinting in the zebrafish has important ramifications with respect to the evolution of the process as well as for understanding the role of imprinting in mammals.
Who reads Parent-of-origin specific effects on the methylation of a transgene in the zebrafish, Danio rerio?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- C. Cristofre Martin; Ross McGowan
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0192-253X)
- Published
- 1995
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)