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A rational approach for the development of reduced‐size analogues of neuropeptide Y with high affinity to the Y~1~ receptor by Beate Rist; Heike A. Wieland; Klaus-Dieter Willim; Dr Annette G. Beck-Sickinger is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Abstract Four sets of centrally truncated analogues of neuropeptide Y have been synthesized. In each series the N‐terminal part was constant, while the C‐terminal segment was systematically varied in length. The C‐ and N‐terminal parts were linked by 6‐aminohexanoic acid. The affinity to the Y~1~ receptor was investigated on human neuroblastoma cells SK‐N‐MC. Significant differences were found between the series of peptides as well as within each set. Remarkably, the affinity did not solely depend on the length of the segment, and with increasing numbers of residues the IC~50~ values were not always decreased. With a given N‐terminal segment, only one optimal length of the C‐terminal segment was found, which suggests that it is not the amino acids themselves but their 3D arrangement and orientation that is important for high receptor affinity.

Who reads A rational approach for the development of reduced‐size analogues of neuropeptide Y with high affinity to the Y~1~ receptor?

Author

Beate Rist; Heike A. Wieland; Klaus-Dieter Willim; Dr Annette G. Beck-Sickinger

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1075-2617)

Published

1995

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)