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Dipeptide YA is Responsible for the Positive Effect of Oyster Hydrolysates on Alcohol Metabolism in Single Ethanol Binge Rodent Models by Siregar, Adrian S.; Nyiramana, Marie Merci; Kim, Eun-Jin; Shin, Eui-Jung; Woo, Min Seok; Kim, Jin-Mok; Kim, Jung Hwan; Lee, Dong Kun; Hahm, Jong Ryeal; Kim, Hyun Joon; Kim, Chang-Woon; Kim, Nam-Gil; Park, Si-Hyang; Choi, Yeung Joon; Kang, Sang Soo; Hong, Seong-Geun; Han, Jaehee; Kang, Dawon is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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Accumulative alcohol hangovers cause liver damage through oxidative and inflammatory stress. Numerous antioxidant and anti-inflammatory reagents have been developed to reduce alcohol hangovers, but these reagents are still insignificant and have limitations in that they can cause liver toxicity. Oyster hydrolysate (OH), another reagent that has antioxidant and anti-inflammatory activity, is a product extracted through an enzymatic hydrolysis process from oysters (Crassostrea gigas), which can be easily eaten in meals. This study was aimed at determining the effects of OH on alcohol metabolism, using a single high dose of ethanol (EtOH) administered to rodents, by monitoring alcohol metabolic enzymes, oxidative stress signals, and inflammatory mediators. The effect of tyrosine-alanine (YA) peptide, a main component of OH, on EtOH metabolism was also identified. In vitro experiments showed that OH pretreatment inhibited EtOH-induced cell death, oxidative stress, and inflammation in liver cells and macrophages. In vivo experiments showed that OH and YA pre-administration increased alcohol dehydrogenase, aldehyde dehydrogenase, and catalase activity in EtOH binge treatment. In addition

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Author

Siregar, Adrian S.; Nyiramana, Marie Merci; Kim, Eun-Jin; Shin, Eui-Jung; Woo, Min Seok; Kim, Jin-Mok; Kim, Jung Hwan; Lee, Dong Kun; Hahm, Jong Ryeal; Kim, Hyun Joon; Kim, Chang-Woon; Kim, Nam-Gil; Park, Si-Hyang; Choi, Yeung Joon; Kang, Sang Soo; Hong, Seong-Geun; Han, Jaehee; Kang, Dawon

Publisher

MDPI Publishing; MDPI AG; Multidisciplinary Digital Publishing Institute (MDPI); Basel: MDPI, 2003- (ISSN 1660-3397)

Published

2020

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)